Certain side effects can occur in women who take HT. Forty percent of women who have not had a hysterectomy and who are starting to take estrogen and a progestogen will have irregular breakthrough bleeding during the first three to six months. In most cases bleeding stops within 12 months, but for some women it may continue beyond a year. This side effect is much less common in women who are taking to combination tablet of conjugated estrogen with bazedoxifene. Any woman experiencing unexpected bleeding after menopause should speak to their doctor.
Women taking estrogen therapy may experience breast tenderness, nausea, headache and bloating. These symptoms can often be treated by changing the dosage, schedule, or route of medication.